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Tizanidine

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Product Name Price Shipping Total Order
Tizanidine  (Generic Tizanidine ) 4mg – 180 Tabs $156 free $156 Order
Tizanidine (Generic Tizanidine ) 4mg – 180 Tabs $156 free $156 Order

Tizanidine is a short-acting muscle relaxer. It works by blocking nerve impulses (pain sensations) that are sent to your brain.

Tizanidine is used to treat spasticity by temporarily relaxing muscle tone.

Tizanidine may also be used for purposes not listed in this medication guide.

Generic Name: tizanidine (tye ZAN i deen)
Brand Names: Zanaflex

Zanaflex (Generic Tizanidine)
Zanaflex (Generic Tizanidine)

Important information

You can buy Zanaflex (Generic Tizanidine) online only when you know its precautions and side effects. You must refill your order here.

We do not sell any prescriptions to first time patients. You must have your health conditions checked with your local physical doctors and you can refill your Zanaflex (Generic Tizanidine)  here in our websites.

Tizanidine is a short-acting medication that should be taken only for daily activities that require relief from muscle spasticity.

You should not take tizanidine if you are also taking fluvoxamine (Luvox) or ciprofloxacin (Cipro).

Do not use tizanidine at a time when you need muscle tone for safe balance and movement during certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone.

Switching between tablets and capsules, or changing the way you take it with regard to eating, can cause an increase in side effects or a decrease in therapeutic effect. Follow your doctor’s instructions carefully. After making any changes in how you take tizanidine, contact your doctor if you notice any change in how well the medicine works or if it causes increased side effects.

Do not take more than three doses (36 mg) of tizanidine in a 24-hour period. Too much of this medicine can damage your liver. Cold or allergy medicine, narcotic pain medicine, sleeping pills, other muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by tizanidine.

Avoid drinking alcohol. It can increase some of the side effects of this medicine.

Before taking tizanidine

You should not use tizanidine if you are allergic to it, or if:

  • you also take the antidepressant fluvoxamine (Luvox); or
  • you also take the antibiotic ciprofloxacin (Cipro).

To make sure this medicine is safe for you, tell your doctor if you have:

  • liver disease;
  • kidney disease; or
  • low blood pressure.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether tizanidine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take tizanidine?

Take tizanidine exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

In most cases you may take tizanidine up to 3 times in one day if needed. Allow 6 to 8 hours to pass between doses.

You may take tizanidine with or without food, but take it the same way each time. Switching between taking with food and taking it without food can make the medicine less effective or cause increased side effects.

Switching between tablets and capsules can also cause changes in side effects or how well the medicine works.

  • Taking the tablets with food can increase your blood levels of tizanidine.
  • Taking the capsules with food can decrease your blood levels of tizanidine.

Follow your doctor’s instructions carefully. After making any changes in how you take tizanidine, contact your doctor if you notice any change in side effects or in how well the medicine works.

Tizanidine is a short-acting medication, and its effects will be most noticeable between 1 and 3 hours after you take it. You should take this medicine only for daily activities that require relief from muscle spasms.

Do not take more than three doses (36 mg) in a 24-hour period. Too much of this medicine can damage your liver.

You will need frequent blood tests to check your liver function.

If you stop using this medicine suddenly after long-term use, you may have withdrawal symptoms such as dizziness, fast heartbeats, tremors, and anxiety. Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture and heat.

tizanidine Usual Adult Dose for:

    • Muscle Spasm

Additional dosage information:

      • Renal Dose Adjustments
      • Liver Dose Adjustments
      • Dose Adjustments
      • Precautions
      • Dialysis
      • Other Comments

Usual Adult Dose for Muscle Spasm

Initial dose: 2 mg orally every 6 to 8 hours as needed
-Peak effects occur in approximately 1 to 2 hours and last for 3 to 6 hours; treatment can be repeated as needed to a maximum of 3 doses in 24 hours; gradually increase dose by 2 to 4 mg at intervals of 1 to 4 days until satisfactory reduction of muscle tone is achieved.
Maximum single dose: 16 mg
Maximum daily dose: 36 mg in 24 hours

Comments:
-Clinically significant differences in absorption are expected between capsules and tablets when taken with or without food; these differences could result in changes in efficacy and tolerability.
-Once a formulation is decided on and a decision is made to take with or without food, this regimen should not be altered.

Use: Management of spasticity.

Renal Dose Adjustments

Severe renal impairment (CrCl less than 25 mL/min): Individualize therapy with lower doses during dose titration; if higher doses are required, individual doses should be increased rather increasing the dosing frequency; closely monitor for toxicity

Liver Dose Adjustments

Not recommended

Dose Adjustments

Use with caution in elderly patients, especially those with renal impairment.

Drug withdrawal:
-Decrease by 2 to 4 mg per day, especially in patients who have been receiving doses of 20 to 36 mg per day for periods of 9 weeks or more.

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-May take orally with or without food; however, once a formulation is decided on and a decision is made to take with or without food, this regimen should not be altered.

General:
-Because this drug has a relatively short duration of effect, dosing should occur at times when relief of spasticity is most important, such as before activities of daily living.
-Considerable variation in response has been observed and therefore careful titration is necessary in order to not exceed the dose producing the desired effect.
-Gradual dose reduction is advised on discontinuation so as to minimize risk of withdrawal and rebound hypertension, tachycardia, and hypertonia.

Monitoring:
-Obtain aminotransferase levels at baseline, 1 month after maximum dose is achieved, and as clinically indicated (e.g. if hepatic injury is suspected).
-Consider obtaining baseline renal function in elderly patients.
-Monitor for hypotension in at-risk patients and those receiving concomitant antihypertensive therapy.
-Monitor for sedation in patients receiving concomitant CNS depressant agents.

Patient advice:
-Patients may take this drug with or without food, but once the decision is made to take with or without food it should be taken this way consistently.
-Patients should check with their healthcare provider before starting or stopping any medications as this drug is known to interact with other medications.
-Patients should be advised not to abruptly stop taking this medication without first talking with their healthcare provider.
-Patients should be advised that this drug may cause hypotension and they should be careful when changing positions form lying to standing.
-Patients should be advised this drug may cause significant somnolence, especially if taken with other CNS depressants or alcohol; they should refrain from activities requiring mental alertness until the effects of the drug are known.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include weakness, drowsiness, confusion, slow heart rate, shallow breathing, feeling light-headed, or fainting.

What should I avoid while taking tizanidine?

Do not use tizanidine at a time when you need muscle tone for safe balance and movement during certain activities. In some situations, it may be dangerous for you to have reduced muscle tone.

Drinking alcohol with this medicine can cause side effects.

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Tizanidine side effects

Get emergency medical help if you have signs of an allergic reaction to tizanidine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • weak or shallow breathing;
  • confusion, hallucinations; or
  • pain or burning when you urinate.

Common tizanidine side effects may include:

  • drowsiness, dizziness, weakness;
  • feeling nervous;
  • blurred vision;
  • flu-like symptoms;
  • dry mouth, trouble speaking;
  • abnormal liver function tests;
  • runny nose, sore throat;
  • urination problems;
  • vomiting, constipation; or
  • uncontrolled muscle movements.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Along with its needed effects, tizanidine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tizanidine:

More common

  • Chest pain or discomfort
  • fever or chills
  • nausea or vomiting
  • nervousness
  • pain or burning while urinating
  • unusual tiredness

Less common

  • Blurred vision
  • flu-like symptoms
  • irregular heartbeat
  • itching skin
  • kidney stones
  • right upper stomach tenderness
  • seeing things that are not there
  • shortness of breath
  • weight gain

Incidence not known

  • Continuing vomiting
  • general feeling of tiredness or weakness
  • headache
  • light-colored stools

Get emergency help immediately if any of the following symptoms of overdose occur while taking tizanidine

Symptoms of overdose tizanidine

  • Blurred vision
  • change in consciousness
  • chest pain or discomfort
  • confusion
  • decreased awareness or responsiveness
  • difficult or troubled breathing
  • dizziness, faintness or lightheadedness when getting up from a lying position
  • irregular, fast or slow, or shallow breathing
  • lightheadedness, dizziness, or fainting
  • loss of consciousness
  • pale or blue lips, fingernails, or skin
  • severe sleepiness
  • sleepiness or unusual drowsiness
  • slow or irregular heartbeat
  • sweating
  • unusual tiredness or weakness

Some side effects of tizanidine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Dizziness or lightheadedness, especially when getting up from a lying or sitting position
  • drowsiness
  • dry mouth
  • fatigue
  • sleepiness
  • weakness

Less common

  • Constipation
  • nervousness
  • sore throat

What other drugs will affect tizanidine?

Taking tizanidine with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all your current medicines and any you start or stop using, especially:

      • acyclovir;
      • ticlopidine;
      • zileuton;
      • birth control pills;
      • an antibiotic – ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, or ofloxacin;
      • blood pressure medicine – clonidine, guanfacine, methyldopa;
      • heart rhythm medicine – amiodarone, mexiletine, propafenone, verapamil; or
      • stomach acid medicine – cimetidine, famotidine.

This list is not complete. Other drugs may interact with tizanidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

If you have some concern for tizanidine , please ask it in the muscle relaxant forums

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